Advanced IVIVC Professional

Topics

• Perform calculation to establish IVIVC
• Summary about the basis on IVIVC
• Time scaling problems, linear, non linear, use of inverse functions
• Absorption determination: basis & advance calculations estimation in case of flip-flop
• Calculate the optimal furmulation`s target dissolution curve
• Non linear relationship
• How to integrate in vivo variability in the calculations
• IVIVC as Biowaivers: Case studies
• Case of metabolites, another approach of Level C
• Common problems: when to average data, us of median, improvement of bioavailability, lag time correction
• Case of Long acting drugs
• Case of DPI and nonstandard formulations, ratio approach