Bioinformatics & Drug Discovery Technology 2015 is a seminar dedicated to the latest science and technology used in bioinformatics and drug discovery & designing. the course will be of great help to students/ researchers/ scientists in learning this latest science and technology.
Topics
- Homology Modeling – Modeller and Swiss Modeling
- Sequence Alignment - Pairwise Sequence Alignment – Blast, Multiple Sequence Alignment – Clustalw, ClustalX, Clustal Omega
- Protein-Protein Interaction Analysis – String and Mint databases
- Protein Domain Analysis – Interproscan
- Introduction of Drug Discovery & Designing
- Basic Linux commands and Perl and Bioperl programming
- Virtual screening
- Science involved in disease target identification
- Conversion of Mol files to Pdb files by Open Babel
- In-silico generation of ligands by ChemSketch
- Molecular Docking by MGL Tools
- Protein optimization & Energy Minimization by SPDV
- Running the Docking Algorithm by Cygwin
- Creation of Grid Parameter & Dock Parameter files by AutoDock Software
- Look for H-bond Between ligand and active site of the residue of protein by UCSF Chimera
- Selection of potent inhibitors on the basis of binding energies and Lipinski`s Rule of 5
- Prediction of Bioactivity
- Prediction of Molecular Properties
- Bioavailability & ADME
- Drug Likeness
- Toxicity
Who should Attend
Researchers, students and scientists.
