Epigenetics is a research area of the changes in cellular phenotype or gene expression, expanding beyond oncology into inflammatory, neurological, metabolic, infectious and rare diseases.
Topics
- Lead optimisation and candidate biomarker identification
- Biophysical, biochemical, label-free and high-throughput screening
- Utilising DNA methylation data to elucidate the druggability of epigenetic readers, writers and erasers
- Functional analysis, validation and interpretation of data obtained using ChIP, bisulphite, chemoproteomic, single-cell and microarray assays
- Isoform-specific HDAC inhibitors for autoimmune and rheumatic diseases
- Target-based drug discovery for histone deacetylases and methyltransferases in oncology, inflammatory and infectious diseases
- Therapies in clinical development for epileptic, psychotic, rare and malignant diseases
- The role of position-effect variegation and genomic imprinting in sexually dimorphic and neurodevelopmental disorders
- Strategic acadæmia-industry and industry-industry partnering and collaborations
- The epigenomic basis and regulation of drug resistance in solid tumours
