Description
Mechanisms of gene regulation mediated by small RNAs, including microRNAs, siRNAs and piRNAs, play critical roles in processes central to the growth and metabolism of eukaryotic cells and to the development and homeostasis of tissues and organs in humans. Genetic, molecular and biochemical research into RNA silencing, employing model organisms and/or human cells and tissues, continues to reveal new insights and understanding of processes fundamental to human development and disease.