Organometallic Chemistry - from Magnesium to Palladium 2018

Topics

• Catalytic Organometallic Reagents
  • Metal catalysed C-C bond forming reactions, Biaryl coupling reactions and Heck reactions, Aromatic cyanation, Hydroformylation
  • Introduction; Metals, Ligands, Catalytic cycles
  • Catalysis with cheaper metals (Ni, Cu, Fe, Co), Ni and Cu as alternatives to Pd, Fe and Co catalysed reactions
  • Industrial Case Studies and Scale Up
  • Metal catalysed C-X bond forming reactions, Buchwald-Hartwig Coupling, Migita Coupling, Other C-X bond forming reactions
  • Other transition metal catalysed reactions (Rh, Ru, Ir, and Au); Asymmetric C-C bond formation, Borrowing hydrogen chemistry, Hydrogen mediated bond forming reactions
• Stoichiometric Organometallic Reagents
  • Making and Handling Organolithiums, Grignards and Organozincs, Metal halogen exchange, Directed metalation
  • Introduction; Bonding, reactivity
  • Using Grignard reagents, Case studies using organomagnesium reagents
  • Safety Issues, Stability of reagents and intermediates, Exotherms and potential runaways
  • Organolithium and organozinc reagents
  • Recent developments in Grignard Chemistry, New chemistry and new technology using Grignard reagents

Who should Attend

• Discovery Chemists
• Process Chemists
• Experienced Chemists
• Production Chemists
• New Starters
• Students
• Managers