Ubiquitin Biology

Topics

• What are the major factors that limit ubiquitin proteasome function during disease pathogenesis
• Can individual cellular pathways, like DNA repair, be specifically manipulated by altering the activity of ubiquitin pathway enzymes
• Detailed connections between the diverse cellular pathways regulated by the ubiquitin system
• How do infectious diseases impact the ubiquitin system, and can we utilize these diverse mechanisms to develop new tools and paradigms to manipulate the ubiquitin system
• Emerging themes using by pathogens to subvert the ubiquitin system
• The structural rules defining how individual proteins are specifically targeted by ubiquitin pathway enzymes