Medicinal Chemistry

Topics

• Introduction to Medicinal Chemistry, definitions, QSAR studies, drug receptors, physico-chemical properties
• Introduction: Overview of drug discovery process, target selection in the post-genomic era
• Lead generation approaches
• Physico-chemical properties of drugs, and implications for Absorption
• Molecular diversity and combinatorial design
• Lead generation using computational techniques: molecular recognition, structure- and ligand-based virtual screening, success stories
• Introduction to Lead Optimisation, Case Studies
• Pharmacokinetics and ADME, with examples
• Intellectual property issues related to drug discovery
• Overview of some of the reasons for project failure, of Safety, in particular to its relationship to chemical structure and of critical issues in Drug Development
• What happens next? – a (very) brief overview of process development issues

Who should Attend

• Chemists
• Medicinal chemists
• Students