Secrets of Batch Process Scale-Up

Topics

• Scale-Up - An Overview
  • Overview of scale-up issues
  • Role of the Pilot Plant
  • Technology transfer issues
• Process Design for Scale-Up
  • Importance of engineering in PDs
  • Process development strategies
• Raw Materials
  • Large-scale charging methods and issues
  • Raw material and route selection
• Batch Reactors
  • Characteristics of batch operations
  • Typical plant operations and equipment
• Following Reaction Progress
  • Sampling methods / issues
  • Reaction endpoint determination
  • On-line analytical techniques
• Temperature Control
  • Heat transfer in batch reactors
  • Large scale temperature control
  • Controlling exothermic reactions
• Quench & Work-Up
  • Phase continuity issues and emulsions
  • Liquid-liquid extractions
• Agitation and Mixing
  • Mixing limited reaction
  • Large scale mixing equipment
  • Mixing scale-up / scale-down
• Crystallization and Precipitation
  • Controlling supersaturation
  • Basic principles / yield estimation
  • Scale-up issues
• Distillation & Stripping
  • Azeotropes and solvent exchange
  • Differential distillation
• Process Hazards and Safety Assessment
  • Process hazard assessments and evaluations
  • Common hazards in large-scale processing
• Product Isolation and Drying
  • Filtration and drying equipment
  • Large-scale solid-liquid separations
  • Filtration and drying modelling